骨关节炎是一种慢性、高发性关节退行性病变,其患病率逐年递增, 给社会带来了沉重的经济负担, 并严重威胁公共卫生健康。铜死亡(cuproptosis)是一种铜依赖性非凋亡调节的细胞死亡形式,其调控过程涉及多种信号分子的参与。近年来研究证实,铜死亡与骨关节炎的进展密切相关, 其可通过调控炎症反应、氧化应激等关键病理生理过程,影响骨关节炎的发生和发展。本文就铜死亡对骨关节炎的调控作用及相关机制进行梳理与总结,以期为骨关节炎的临床治疗提供新的思路和策略。

Osteoarthritis is a chronic and highly prevalent joint degenerative disease with an increasing prevalence year by year, which imposes a heavy economic burden on society and seriously threatens public health. Cuproptosis is a copper-dependent non-apoptotic regulated form of cell death, and its regulatory process involves the participation of various signaling molecules. Recent studies have confirmed a close link between cuproptosis and the progression of osteoarthritis. It influences the onset and development of osteoarthritis by regulating key pathophysiological processes such as inflammatory responses and oxidative stress. This article combs and summarizes the regulatory effect of cuproptosis on osteoarthritis and its related mechanisms, aiming to provide new ideas and strategies for the clinical treatment of osteoarthritis.