分子伴侣介导的自噬(chaperone-mediated autophagy, CMA)是一种高度选择性的细胞内降解途径,在维持细胞稳态和疾病的发生发展中发挥关键作用，CMA 通过调控蛋白质稳态、介导应激反应、调节细胞周期、参与铁死亡调控以及维持线粒体功能，对细胞稳态产生重要影响，其功能紊乱与多种疾病的发生发展密切相关。近年来，CMA 在肺部疾病中的作用逐渐受到关注。本文旨在综述CMA 在肺癌、慢性阻塞性肺疾病和急性肺损伤中的作用及其机制最新研究进展，以期为肺部疾病的治疗提供新思路。

Chaperone-mediated autophagy (CMA) is a highly selective intracellular degradation pathway that plays a pivotal role in maintaining cellular homeostasis, as well as in the onset and progression of disease. CMA significantly influences cellular homeostasis by regulating protein homeostasis, mediating stress responses, modulating the cell cycle, contributing to the regulation of ferroptosis, and sustaining mitochondrial function. Dysfunction of CMA is closely associated with the development of numerous diseases. In recent years, the role of CMA in pulmonary diseases has received increasing attention. This review summarizes the latest research on the role and mechanisms of CMA in lung cancer, chronic obstructive pulmonary disease and acute lung injury, with the aim of providing novel insights into the treatment of pulmonary disorders.