咖啡(coffee)是一种全球广泛消费的饮品,它具有多种生物活性成分,包括咖啡因、葫芦巴 碱、多酚类化合物及二萜类化合物等。这些生物活性成分可通过多靶点机制展现抗结直肠癌 (colorectal cancer)潜力,潜在的分子机制包括抑制Wnt/β-catenin通路、调控氧化应激、激活免疫 应答、促进结直肠癌细胞凋亡与抑制生长、迁移等。研究表明,咖啡摄入可显著降低晚期结直肠癌 患者的死亡率,改善预后。本文系统综述咖啡主要成分的生物学效应与临床关联,以期为结直肠癌 防治的膳食干预提供理论依据。

Coffee, a globally consumed beverage, contains multiple bioactive compounds, including caffeine, trigonelline, polyphenols, and diterpenes. These bioactive constituents exhibit potential anti-colorectal cancer effects through multi-target mechanisms, including suppression of the Wnt/β-catenin pathway, modulation of oxidative stress, activation of immune responses, and promotion of cancer cell apoptosis, while inhibiting growth and migration of colorectal cancer cells. Research indicates that coffee consumption significantly reduces mortality and improves prognosis for patients with advanced colorectal cancer. This article systematically reviews the biological effects and clinical relevance of coffee' s primary constituents, aiming to provide a theoretical basis for dietary interventions in the prevention and treatment of colorectal cancer.