沉默信息调节因子3(silent information regulator 3,SIRT3)作为沉默信息调节因子家族中的一员,主要调控线粒体代谢,在年龄相关疾病、神经退行性疾病、心肝肾和代谢疾病中具有重要作用,尤其在癌症中兼具抑癌和促癌双重作用,被认为是极具前景的疾病治疗靶点。本文系统梳理了SIRT3在肿瘤发生发展中的复杂分子机制及其在结直肠癌、肺癌、肝癌、卵巢癌、胆囊癌/胆管癌和胰腺癌等多种恶性肿瘤中的作用研究进展。阐明SIRT3的作用机制不仅有助于揭示肿瘤发病的分子基础,更有望推动以SIRT3为靶点的新型抗肿瘤药物的研发,为临床癌症治疗提供新的方向。

Silent information regulator 3(SIRT3), a member of the silent information regulator family, primarily regulates mitochondrial metabolism, and plays a critical role in age-related diseases, neurodegenerative disorders, as well as cardiac, hepatic, renal, and metabolic diseases. Notably, in cancer, SIRT3 exhibits both tumor-suppressive and tumor-promoting functions, making it a promising therapeutic target. This review systematically summarizes the complex molecular mechanisms of SIRT3 in tumorigenesis and its roles in various malignant tumors, including colorectal cancer, lung cancer, hepatocellular carcinoma, ovarian cancer, gallbladder cancer,cholangiocarcinoma,and pancreatic cancer. Elucidating the mechanisms of SIRT3 not only contributes to revealing the molecular basis of tumorigenesis, but also holds promise for promoting the development of novel antitumor agents targeting SIRT3, thereby providing new directions for clinical cancer therapy.