血管生成是胚胎发育和个体发育的关键环节,血管生成的异常与肿瘤、动脉粥样硬化和老年黄斑变性等多种疾病密切相关。近年来研究表明,血管生成具有昼夜节律性,作为昼夜节律核心调控分子的BMAL1(brain and muscle Arnt-like 1 protein)在血管生成中发挥着重要作用。本文通过综述BMAL1在调控内皮细胞增殖与迁移、血管成熟和血管稳态中的作用与机制,为深入了解血管生成的分子机制及在此基础上开发血管靶向药物奠定基础。

Angiogenesis is a key process in both embryonic and postnatal individual development, and its dysregulation is closely associated with various diseases, such as tumors, atherosclerosis, and age-related macular degeneration. Recent studies have shown that angiogenesis exhibits circadian rhythmicity, with BMAL1(brain and muscle Arnt-like 1 protein), a core regulator of the circadian clock, playing a critical role in this process. In this article, we review the role and mechanism of BMAL1 in regulating endothelial cell proliferation and migration, vascular maturation, and vascular homeostasis, providing a foundation for a deeper understanding of the molecular mechanism of angiogenesis and the development of vascular-targeted therapies.