抑郁症是一种严重的精神障碍,给患者和社会带来沉重负担。咖啡作为一种被广泛消费的饮料,富含咖啡因、绿原酸和二萜醇等多种生物活性成分。研究表明,这些成分可通过抑制神经炎症、抗氧化应激和调节神经递质对抑郁症起到防治作用。流行病学研究显示,适量饮用咖啡与罹患抑郁症风险降低显著相关。本文系统综述咖啡活性成分的抗抑郁机制与相关人群研究,旨在为合理饮用咖啡提供科学参考。

Depression is a serious psychiatric disorder that imposes a heavy burden on patients and society. As a widely consumed beverage, coffee is rich in various bioactive components such as caffeine, chlorogenic acid, and diterpenes. Previous studies have indicated that these components may play a role in the prevention and treatment of depression by inhibiting neuroinflammation, combating oxidative stress, and regulating neurotransmitters. Epidemiological studies have demonstrated a significant association between moderate coffee consumption and a reduced risk of depression. This article systematically reviews the antidepressant mechanisms of coffee's bioactive components and related population-based studies, aiming to provide a scientific reference for rational coffee consumption.