生理科学与临床

“咖啡与健康”系列——咖啡与皮肤健康:抗衰老、光防护及促修复作用

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  • (1 北京大学基础医学院;2 北京大学基础医学院生物化学与分子生物学系; 3 北京大学基础医学院系统生物医学研究所,北京 100191)
△ congyingwu@bjmu.edu.cn; yangsh@bjmu.edu.cn

收稿日期: 2025-07-23

  修回日期: 2025-08-29

  录用日期: 2025-09-04

  网络出版日期: 2025-10-25

基金资助

北大医学瑞幸健康创新基金RX-CX202501资助课题 △ 通信作者 congyingwu@bjmu.edu.cn; yangsh@bjmu.edu.cn

Coffee and Skin Health: Anti-Aging, Photoprotective, and Reparative Effects

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  • (1School of Basic Medical Sciences, Peking University; 2Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University; 3Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University, Beijing 100191, China)
△ congyingwu@bjmu.edu.cn; yangsh@bjmu.edu.cn

Received date: 2025-07-23

  Revised date: 2025-08-29

  Accepted date: 2025-09-04

  Online published: 2025-10-25

摘要

咖啡中的成分对皮肤健康具有多方面影响。研究表明,咖啡因可促进自噬和清除活性氧, 显著减少氧化应激,从而延缓皮肤衰老(skin aging)并增强皮肤弹性。绿原酸则通过抗氧化和抗炎作用,抑制炎症因子的产生,减轻皮肤炎症反应,进而延缓皮肤衰老并降低皮肤癌风险。咖啡豆烘焙过程中绿原酸部分分解产生的阿魏酸在抗炎抗氧化功能的基础上对紫外线具有吸收和反射作用,可减少紫外线诱导的DNA 损伤,增强皮肤屏障功能。此外,咖啡因还能刺激皮肤细胞增殖和迁移,加速伤口愈合。本文系统阐述了咖啡摄入延缓皮肤衰老、预防皮肤癌、光保护以及促进皮肤愈合与再生的作用及其可能机制,探讨了咖啡及其成分在皮肤健康保护方面具有的重要作用及可能的应用前景。

本文引用格式

王钦铄1, 赵欣慧2, 吴聪颖3, △, 杨 洋2, △ . “咖啡与健康”系列——咖啡与皮肤健康:抗衰老、光防护及促修复作用[J]. 生理科学进展, 2025 , 56(5) : 463 -467 . DOI: 10.20059/j.cnki.pps.2025.09.1233

Abstract

The components of coffee exert multifaceted effects on skin health. Studies have shown that caffeine promotes autophagy and scavenges reactive oxygen species, significantly reducing oxidative stress, thereby delaying skin aging and enhancing skin elasticity. Chlorogenic acid, through its antioxidant and anti-inflammatory properties, inhibits the production of inflammatory factors and mitigates skin inflammation, consequently slowing skin aging and reducing the risk of skin cancer. Ferulic acid, derived from the partial degradation of chlorogenic acid during coffee bean roasting, not only exhibits anti-inflammatory and antioxidant functions but also absorbs and reflects ultraviolet (UV) radiation, helping to reduce UV-induced DNA damage and enhance the skin barrier function. Furthermore, caffeine stimulates the proliferation and migration of skin cells, thereby accelerating wound healing. This article elaborates on the roles and potential mechanisms of coffee consumption in delaying skin aging, preventing skin cancer, providing photoprotection, and promoting skin repair and regeneration, highlighting the significance and potential applications of coffee and its bioactive constituents in promoting skin health.
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