色氨酸2,3-双加氧酶2(tryptophan 2,3-dioxygenase 2, TDO2 )是介导色氨酸沿犬尿氨酸通路分解代谢的关键酶之一。许多研究表明,TDO2 在多种恶性肿瘤细胞中异常高表达,并与肿瘤的进展、免疫逃逸和肿瘤微环境的免疫抑制紧密相关, 由此 TDO2 成为肿瘤免疫治疗中备受关注的重要靶点。近年来,TDO2 抑制剂被认为可逆转肿瘤的免疫耐受状态,加强机体的免疫应答, 因此在癌症治疗中展示出潜力。本文概述了 TDO2 的结构、功能以及其在免疫调控中的作用, 并重 点介绍了 TDO2 抑制剂在肿瘤治疗中的应用与最新研究进展。

Tryptophan 2,3-dioxygenase (TDO2) is one of the key enzymes that mediates the catabolism of tryptophan along the kynurenine pathway. Numerous studies have shown that TDO2 is aberrantly overexpressed in a variety of malignant tumor cells, and is closely associated with tumor progression, immune evasion, and immune suppression within the tumor microenvironment. Consequently, TDO2 has become an essential target that has attracted significant attention for tumor immunotherapy. In recent years, TDO2 inhibitors have been proposed to reverse the immunotolerant state of tumors, enhancing immune responses in the host, thus showing potential in cancer therapy. This article provides an overview of the structure and function of TDO2, as well as its role in immunoregulation, with a particular focus on the applications of TDO2 inhibitors in cancer therapy and the latest research advancements.