高尿酸血症(hyperuricemia, HUA)是因尿酸在体内过度蓄积造成的一种代谢性疾病。大量研究表明,HUA 与多种生殖系统疾病密切相关,如勃起功能障碍、多囊卵巢综合征及子宫内膜异位症等。本文综述了国内外关于HUA 与生殖障碍关系的研究进展,重点探讨了氧化应激、炎症反应、内皮功能障碍和肠道菌群等生物学机制在生殖功能紊乱中的潜在作用,旨在为深入探究高尿酸血症引发生殖疾病的机制以及制定相应的治疗策略提供参考依据。

Hyperuricemia (HUA) is a metabolic disorder resulting from the excessive accumulation of uric acid in the body. Numerous studies have demonstrated that HUA is closely associated with various reproductive disorders, including erectile dysfunction, polycystic ovary syndrome, and endometriosis. This article presents a comprehensive review of research progress on the relationship between HUA and reproductive disorders, both domestically and internationally. Specifically, it focuses on the potential roles of biological mechanisms, such as oxidative stress, inflammatory responses, endothelial dysfunction, and alterations in the gut microbiota, in the development of reproductive dysfunction. This review aims to offer insights into the mechanisms underlying hyperuricemia-induced reproductive disorders, and to inform potential therapeutic strategies.