线粒体是执行和协调细胞中各种代谢过程的重要细胞器,线粒体功能障碍严重影响细胞健康并导致疾病。维持线粒体健康依赖于线粒体膜网络的动态变化和有效的线粒体质量控制机制。越来越多的研究表明,线粒体与内质网之间形成的线粒体相关内质网膜(mitochondria- associated endoplasmic reticulum membranes, MAMs)结构在调控线粒体质量控制中发挥重要作用。本文综述了MAMs在调控线粒体质量控制中的研究进展,揭示了MAMs的结构和功能改变与线粒体质量控制失调密切相关,为理解和治疗相关疾病提供了新的视角和潜在的治疗靶点。未来的研究需要进一步明确MAMs在不同疾病中的具体调控机制,以及开发有效的干预策略,以期实现对相关疾病的精准治疗。

Mitochondria are essential organelles that execute and coordinate various metabolic processes in cells. Mitochondrial dysfunction significantly affects cellular health and leads to a variety of diseases. The maintenance of mitochondrial health depends on dynamic changes in the mitochondrial membrane network and effective mitochondrial quality control mechanisms. Increasing evidence suggests that mitochondria-associated endoplasmic reticulum membranes (MAMs), formed between mitochondria and the endoplasmic reticulum, play a crucial role in regulating mitochondrial quality control. This article reviews the research progress of MAMs in regulating mitochondrial quality control, revealing that the structural and functional changes of MAMs are closely related to disorders of mitochondrial quality control, providing new perspectives and potential therapeutic targets for understanding and treating associated diseases. Future studies need to further clarify the specific regulatory mechanisms of MAMs in different diseases and develop effective intervention strategies, with the aim of achieving precise treatment of associated diseases in clinical practice.