肌肉骨骼系统疾病是运动损伤及年龄相关性退化的常见并发症,显著损害运动能力和生活质量。因此,识别并筛选新型干预靶点对肌肉骨骼疾病的康复及治疗至关重要。目前的研究显示, Piezo1门控通道可通过多重信号级联途径及机制调控肌骨系统包括肌卫星细胞、骨骼、肌腱和椎间盘的代谢稳态,并参与肌骨系统相关疾病的病理进程,是肌骨系统疾病极具潜力的治疗干预靶点。本文系统论述了Piezo1的微观结构、分子调控网络、特异性激动剂和拮抗剂,以及其在肌肉、骨骼、肌腱及椎间盘中的功能作用,以期为肌骨系统疾病的康复及治疗提供新的干预靶点及理论依据。

Musculoskeletal disorders are common complications of sports injuries and age-related degeneration that negatively affect motor function and quality of life.Therefore,identification and screening of novel intervention targets are crucial for the rehabilitation and treatment of musculoskeletal disorders.Current research has indicated that the mechanosensitive channel Piezo1 regulates the metabolic homeostasis of the musculoskeletal system, including satellite cells, bones,tendons, and intervertebral discs, through multiple signaling cascades and molecular mechanisms. Moreover, Piezo1 is involved in the pathogenesis of musculoskeletal disorders, thereby emerging as a potential target for therapeutic intervention. In this article, we systematically discuss the microstructure, molecular regulatory network, and specific agonists and antagonists of Piezo1, as well as its functional roles in skeletal muscles, bones, tendons, and intervertebral discs, aiming to provide novel intervention targets and a theoretical basis for the rehabilitation and treatment of musculoskeletal disorders.