胃食管反流(gastroesophageal reflux disease,GERD)是一种常见的消化系统疾病,其发病机制涉及胃内容物反流至食管,导致食管黏膜损伤和炎症。Claudin蛋白是构成细胞间紧密连接的重要组成部分,通过形成细胞间紧密连接,维持上皮细胞之间的屏障功能,在抗反流防御机制中发挥关键作用。未来claudin蛋白可能成为GERD诊断和治疗的潜在生物学标志物,为研究GERD的发病机制提供新的视角。本文综述了claudin蛋白在GERD患者中的表达变化及其在食管黏膜屏障中可能的作用机制。

Gastroesophageal reflux disease (GERD) is a common digestive disorder characterized by the reflux of gastric contents into the esophagus, leading to mucosal damage and inflammation. Claudin proteins play a crucial role in forming intercellular tight junctions, maintaining the barrier function between epithelial cells, and actively participating in defense mechanisms against reflux. Claudin proteins hold potential as biomarkers for the diagnosis and treatment of GERD, offering a new perspective for understanding the pathogenesis of the disease. This article reviews the changes in the expression of claudin proteins in GERD patients and their potential mechanistic roles in the esophageal mucosal barrier.