甲磺司特在Th2细胞介导疾病中的研究进展

齐芷卉1, 2, 3, 4, #, 朱玺润1, 2, 3, 4, #, 殷 茵1, 2, 3, 5, #, 王革新6, 刘 媛1, 2, 3, 初 明1, 2, 3, 王月丹1, 2, 3, △

doi:10.20059/j.cnki.pps.2024.03.1143

生理科学进展 >

2024 , Vol. 55 >Issue 4: 369 - 375

DOI: https://doi.org/10.20059/j.cnki.pps.2024.03.1143

专论

甲磺司特在Th2细胞介导疾病中的研究进展

展开

(1 北京大学基础医学院免疫学系,北京100191;2 国家卫生健康委员会医学免疫学重点实验室,北京100191; 3北京大学生物医学实验教学中心病原与免疫综合实验室,北京100191;4 北京大学药学院,北京100191; 5北京大学口腔医学院,北京100081;6 南阳医学高等专科学校,南阳473000)

# 等同贡献 △王月丹，E-mail: wangyuedan@bjmu.edu.cn

收稿日期: 2023-11-21

修回日期: 2023-12-20

录用日期: 2023-12-22

网络出版日期: 2024-08-25

基金资助

国家重点研发计划项目(编号SQ2021YFE020462)资助课题

收起

Research Progress on Suplatast Tosilate in Th2 Cell-Mediated Allergic Diseases

Expand

(1Department of Immunology, School of Basic Medicine, Peking University, Beijing 100191, China; 2Key Laboratory of Medical Immunology, National Health Commission, Beijing 100191, China; 3Laboratory of Pathogens and Immunology, Biomedical Experimental Teaching Center, Peking University, Beijing 100191, China; 4Peking University School of Pharmaceutical Sciences, Beijing 100191, China; 5Peking University School and Hospital of Stomatology, Beijing 100081, China; 6Nanyang Medical College, Nanyang 473000, China)

# Co-first △WANG Yue-Dan, Email:wangyuedan@bjmu.edu.cn

Received date: 2023-11-21

Revised date: 2023-12-20

Accepted date: 2023-12-22

Online published: 2024-08-25

Fold

摘要

甲磺司特是一种特异性的Th2细胞抑制剂,已被广泛用于哮喘和特应性皮炎等多种过敏炎症性疾病和其他疾病的治疗,取得了良好的效果并具有很高的安全性。研究表明,甲磺司特可通过调节GATA3和氯离子通道,抑制Th2细胞及IL-4等Th2型细胞因子的产生和功能,从而发挥治疗过敏性疾病的作用;甲磺司特对树突状细胞、单核细胞、嗜酸性粒细胞和神经元等细胞也有调节作用。因此,甲磺司特也成为了治疗Th2细胞介导疾病研究领域关注的焦点。

关键词： 甲磺司特; 过敏反应; Th2细胞; 细胞因子; 炎症

本文引用格式

齐芷卉1, 2, 3, 4, #, 朱玺润1, 2, 3, 4, #, 殷茵1, 2, 3, 5, #, 王革新6, 刘媛1, 2, 3, 初明1, 2, 3, 王月丹1, 2, 3, △ . 甲磺司特在Th2细胞介导疾病中的研究进展[J]. 生理科学进展, 2024 , 55(4) : 369 -375 . DOI: 10.20059/j.cnki.pps.2024.03.1143

Abstract

Suplatast Tosilate is a specific Th2 cell inhibitor that has been widely used in the treatment of various allergic and inflammatory diseases such as asthma and atopic dermatitis, with good efficacy and high safety. Research has shown that Suplatast Tosilate can inhibit the production and function of Th2 cells and Th2-type cytokines such as IL-4 by regulating GATA3 and chloride channels, thereby exerting a therapeutic effect on allergic diseases. Additionally, Suplatast Tosilate also has regulatory effects on dendritic cells, monocytes, eosinophils, and neurons. Therefore, Suplatast Tosilate has become a focus of attention in the research field of treating Th2 cell-mediated allergic inflammatory diseases.

Key words： Suplatast Tosilate; allergic reaction; Th2 cell; cytokines; inflammation

Options

摘要页面

文章导航

模态框（Modal）标题

摘要

本文引用格式

Abstract