血管内皮细胞分泌的内皮素-1(endothelin-1, ET-1)因具有强缩血管效应,最初被认为是高血压致病因子;而后发现在肾内合成和分泌的ET-1具有利尿和利钠作用,也被认为是抗高血压因子。ET-1通过刺激两种G蛋白偶联受体—内皮素受体A、内皮素受体B调控电解质平衡。本文就ET-1对肾脏NaCl重吸收的调节及其机制的研究进展作一综述,以阐述其在血压调节过程中的重要性。

Endothelin-1 (ET-1), secreted by vascular endothelial cells, was initially considered a pathogenic factor for hypertension due to its potent vasoconstrictive effect. However, it was later discovered that ET-1 synthesized and secreted in the kidney exhibits diuretic and natriuretic effects, suggesting a potential antihypertensive role. ET-1 regulates electrolyte balance by stimulating two G protein-coupled receptors, endothelin receptor A and endothelin receptor B. In this article, we review the regulation of renal NaCl reabsorption by ET-1 and the underlying mechanisms, highlighting the significant role of ET-1 in the regulation of blood pressure.