帕金森病是常见的神经系统退行性疾病,发病率逐年升高,其病理特征主要表现为中脑黑质致密部多巴胺能神经元退行性变及α-突触核蛋白的异常聚集。内质网对于蛋白质折叠修饰、加工、运输发挥重要作用。内质网稳态被破坏则会导致未折叠蛋白质、错误折叠蛋白质的积累,诱导内质网应激,导致细胞凋亡。为维持内质网功能和稳态,内质网质量控制系统即未折叠蛋白反应、内质网相关蛋白质降解途径和内质网自噬发挥了作用。研究提示内质网应激与帕金森病的发病有着紧密的联系,但内质网质量控制系统在帕金森病进展中的作用尚不清晰。本文对内质网质量控制系统异常与帕金森病发生发展的关系进行综述,为探索帕金森病的发病机制提供新的思路。

Parkinson's disease, a common neurodegenerative disease with an increasing incidence annually, is characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta and abnormal aggregation of α-synuclein. The endoplasmic reticulum (ER) plays an important role in protein folding modification, processing, and transport. The disruption of ER homeostasis can lead to the accumulation of unfolded and misfolded proteins, inducing ER stress and leading to cell apoptosis. To maintain ER function and homeostasis, the ER quality control system, consisting of the unfolded protein response (UPR), ER-associated protein degradation (ERAD) and ER-phagy, comes into play. Research has indicated that ER stress is closely associated with the onset of Parkinson's disease, but the role of the ER quality control system in the progression of Parkinson's disease remains unclear. In this article, we review the relationship between the abnormality in the ER quality control system and the onset and development of Parkinson's disease, providing new insights into exploring the pathogenic mechanisms of Parkinson's disease.