皮肤是机体和外界环境之间的第一道保护性屏障,在保护机体免受外界环境等危险因素造成的损伤方面起着重要的作用。心理应激是人在面对各种压力和挑战时产生的情绪和心理反应,多种因素都可以作为心理应激的应激源。长期的心理应激会造成机体内环境稳态失衡,甚至疾病发生。迄今为止有众多研究表明心理应激可通过神经内分泌反应,导致皮肤细胞功能减弱或异常,从而深刻影响皮肤局部生理功能,引起皮肤屏障功能的显著变化,导致皮肤健康问题产生。本文主要综述心理应激影响皮肤屏障功能的相关研究进展。

The skin is the first line of defense against a multitude of external pathogens and plays an important role in protecting the body from their harm. Psychological stress refers to the emotional and psychological reactions people exhibit when confronted with various stressors and challenges, with a variety of factors serving as potential triggers. Long-term psychological stress can cause an imbalance in body homeostasis, and even result in diseases. Clinical and experimental evidence shows that psychological stress may lead to the dysfunction of skin cells through neuroendocrine reactions, thus profoundly affecting the local physiological functions of the skin, causing significant changes in the skin barrier function, and leading to skin health problems. In this article, we provide an updated overview of the effects of psychological stress on the skin barrier function.