帕金森病(Parkinson' s disease,PD)是中老年人群最常见的神经退行性疾病之一,以运动障碍为主要表现,常合并有自主神经功能紊乱、嗅觉缺失、睡眠失调、精神症状(抑郁、焦虑)和认知功能障碍等非运动症状,而精神症状和认知功能障碍是最常见的PD 相关非运动症状。截止目前, PD相关非运动症状的病理生理学机制尚不清楚。5-羟色胺(5-hydroxytryptamine,5-HT)递质系统参与多种脑功能以及神经精神障碍的病理生理学过程,与PD 相关非运动症状有密切的联系。本文基于前期的相关研究成果,对5-HT 递质系统在PD精神症状及认知障碍中的作用研究进展做一综述,详细阐述脑内5-HT递质系统的分布与功能,以及PD状态下5-HT递质系统的变化,为PD相关精神症状及认知障碍机制的阐明和治疗提供研究资料。

Parkinson's disease (PD) is one of the most common neurodegenerative diseases in the elderly, which is mainly characterized by dyskinesia and is often accompanied by non-motor symptoms (NMS) such as autonomic nervous dysfunction, anosmia, sleep disorders, psychiatric symptoms (depression and anxiety) and cognitive dysfunction. Psychiatric symptoms and cognitive dysfunction are the most common NMS. So far, the mechanisms involved in the pathophysiology of the NMS have been unclear. The serotonin (5-hydroxytryptamine, 5-HT) transmitter system contributes to the pathophysiology of various brain functions and neuropsychiatric disorders, and is closely related to the NMS of PD. This article reviews the research progress in the role of the 5-HT transmitter system in psychiatric symptoms and cognitive impairment associated with PD, expounds the distribution and function of the 5-HT transmitter system in the brain, and illustrates the changes of the 5-HT transmitter system under PD, attempting to provide research data for the understanding and treatment of PD-related psychiatric symptoms and cognitive impairment.