小胶质细胞与神经元在大脑生理状态或病理状态下都进行着广泛的双向通讯,其对于大脑稳态的建立具有重要作用。研究发现,趋化因子 CX3CL1及其受体 CX3CR1在小胶质细胞、神经元及其交互调控中起着重要作用,因此有可能成为多种神经退行性疾病、精神疾病等脑病理状态的新靶点。本文就近年来国内外研究 CX3CL1-CX3CR1信号轴在小胶质细胞、神经元及其交互调控中的作用进行综述。

Microglia and neurons have extensive bidirectional communication in both physiological and pathological brain states, which plays an important role in the establishment of brain homeostasis. It has been found that chemokine CX3CL1 and its receptor CX3CR1 play an important role in intercellular crosstalk between microglia and neurons, so the CX3CL1-CX3CR1 axis may become a new target for various neurodegenerative diseases, mental disorders and other pathological brain states. Here, we review the recent studies on the role of CX3CL1-CX3CR1 signaling axis in microglia's crosstalk with neurons.