髓母细胞瘤(medulloblastoma,MB)是小脑中的一种异质性胚胎肿瘤,好发于儿童且预后不良。缺氧作为实体瘤的主要特征之一,在肿瘤的发生中扮演着重要的角色。HIF-1α介导肿瘤细胞中的缺氧反应信号传导,并调控肿瘤进展、血管生成、细胞存活和侵袭等基因的表达。已证实MB中HIF-1α通过多种途径调控其生长,但鲜见缺氧条件下HIF-1α在MB中具体作用机制的系统综述,这篇综述将针对该调控机制及耐药治疗靶点的前景进行探讨。

Medulloblastoma is a heterogeneous embryonal tumor in the cerebellum that occurs mostly among children with a poor prognosis. As one of the main characteristics of solid tumors, hypoxia plays an important role in tumor genesis. HIF-1α mediates hypoxia signaling in tumor cells, and meanwhile regulates the expression of genes related to tumor progression, angiogenesis, cell survival and invasion. It has been confirmed that HIF-1α regulates the growth of medulloblastoma through a variety of pathways, while few reviews have specifically focused on the roles of HIF-1α in medulloblastoma. In this review, we will discuss the regulatory mechanism and the prospects of drug-resistance therapeutic targets in medulloblastoma.