Osteoarthritis is a chronic and highly prevalent joint degenerative disease with an increasing prevalence year by year, which imposes a heavy economic burden on society and seriously threatens public health. Cuproptosis is a copper-dependent non-apoptotic regulated form of cell death, and its regulatory process involves the participation of various signaling molecules. Recent studies have confirmed a close link between cuproptosis and the progression of osteoarthritis. It influences the onset and development of osteoarthritis by regulating key pathophysiological processes such as inflammatory responses and oxidative stress. This article combs and summarizes the regulatory effect of cuproptosis on osteoarthritis and its related mechanisms, aiming to provide new ideas and strategies for the clinical treatment of osteoarthritis.