Research Progress on the Role of the Meningeal Lymphatic System in Cerebrovascular Diseases

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  • (1Departmentof Anatomy, Histology and Embryology, School of Basic Medical Sciences, Peking University, Beijing 100191, China; 2 Department of Neurosurgery, Peking University First Hospital, Beijing 100034, China; 3 Neuroscience Research Institute, Peking University, Beijing 100191, China)
△ hongzhouduan@bjmu.edu.cn

Received date: 2025-10-02

  Revised date: 2025-12-13

  Accepted date: 2026-01-08

  Online published: 2026-04-25

Abstract

As the leading cause of mortality and long-term disability in China,cerebrovascular diseases present complex pathophysiological mechanisms involving neuroinflammation,immune dysregulation, and secondary brain injury.The seminal discovery of meningeal lymphatic system in 2015 has fundamentally transformed the understanding of central nervous system immune privilege. This system is now recognized as critical for cerebrospinal fluid drainage, metabolic waste clearance,and central nervous system immune surveillance. Recent advances in neuroimaging and molecular biology have elucidated the pivotal role of the meningeal lymphatic system in cerebrovascular disorders, particularly in modulating inflammatory responses, facilitating post-hemorrhagic erythrocyte clearance,and influencing overall disease progression and recovery. This review synthesizes the latest evidence on the functional contributions of the meningeal lymphatic system to cerebrovascular pathophysiology, to deepen the mechanistic understanding and to highlight its promising potential as a novel therapeutic target.

Cite this article

LI Wei-Ye1, # , LIU Tao2, GUO Miao3, DUAN Hong-Zhou2, Δ . Research Progress on the Role of the Meningeal Lymphatic System in Cerebrovascular Diseases[J]. Progress in Physiological Sciences, 2026 , 57(2) : 101 -108 . DOI: 10.20059/j.cnki.pps.2026.02.1320

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