v-ets erythroblastosis virus E26 oncogene homolog 2 (ETS2) is a transcription factor that plays a crucial role in regulating normal physiological processes such as growth and development, as well as in tumorigenesis. Moreover, aberrant expression and activity of ETS2 are closely associated with the pathogenesis and progression of cardiovascular diseases. This review summarizes the latest advances in ETS2 research within the context of cardiovascular diseases, providing new insights for future investigations into the pathogenesis of cardiovascular diseases and the development of therapeutic targets.