Angiogenesis is a key process in both embryonic and postnatal individual development, and its dysregulation is closely associated with various diseases, such as tumors, atherosclerosis, and age-related macular degeneration. Recent studies have shown that angiogenesis exhibits circadian rhythmicity, with BMAL1(brain and muscle Arnt-like 1 protein), a core regulator of the circadian clock, playing a critical role in this process. In this article, we review the role and mechanism of BMAL1 in regulating endothelial cell proliferation and migration, vascular maturation, and vascular homeostasis, providing a foundation for a deeper understanding of the molecular mechanism of angiogenesis and the development of vascular-targeted therapies.