Research Progress on the Role of FcγRs in Cardiovascular Diseases

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  • (1Department of Physiology, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001,China; 2Institute of Basic Medicine Sciences, Chinese Academy of Medical Sciences; School of Basic Medicine, Peking Union Medical College, Beijing 100005, China)
△ yarongzhang2022@163.com

Received date: 2024-12-18

  Revised date: 2025-02-26

  Accepted date: 2025-03-03

  Online published: 2025-10-25

Abstract

Fragment crystallizable γ receptors (FcγRs) are receptors for immunoglobulin G (IgG). Most of them are expressed on the surface of immune cells, and exert relevant biological functions by binding to the Fc region of IgG to form immune complexes. FcγRs are classified into activating and inhibitory types, which exert similar or opposite functions in different cells. In cardiovascular disease research, multiple studies have found that FcγRs expressed on immune and innate cells participate in the occurrence and development of cardiovascular-related diseases such as myocardial infarction, atherosclerosis, and hypertension by activating cell signaling and stimulating the secretion of different cytokines. This article reviews the classification and functions of FcγRs, as well as the research progress on FcγRs in cardiovascular diseases, with the aim of providing new ideas and methods for the prevention and treatment of cardiovascular diseases.

Cite this article

ZHANG Ying-Ge1, 2, ZHANG Ya-Rong2, △ , WANG Jing2 . Research Progress on the Role of FcγRs in Cardiovascular Diseases[J]. Progress in Physiological Sciences, 2025 , 56(5) : 426 -433 . DOI: 10.20059/j.cnki.pps.2025.06.1308

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