Hyperuricemia (HUA) is a metabolic disorder resulting from the excessive accumulation of uric acid in the body. Numerous studies have demonstrated that HUA is closely associated with various reproductive disorders, including erectile dysfunction, polycystic ovary syndrome, and endometriosis. This article presents a comprehensive review of research progress on the relationship between HUA and reproductive disorders, both domestically and internationally. Specifically, it focuses on the potential roles of biological mechanisms, such as oxidative stress, inflammatory responses, endothelial dysfunction, and alterations in the gut microbiota, in the development of reproductive dysfunction. This review aims to offer insights into the mechanisms underlying hyperuricemia-induced reproductive disorders, and to inform potential therapeutic strategies.