The liver plays a crucial role in the transformation and clearance of xenobiotics.However, continuous exposure to high concentrations of these foreign substances can lead to liver damage,known as drug-induced liver injury (DILI).The pregnane X receptor (PXR), a member of the nuclear receptor superfamily,is a key regulator of hepatic drug clearance.PXR regulates the expression of drug-metabolizing enzymes and transporters,and plays an essential role in drug transformation, metabolism, and clearance in the liver. Studies have shown that PXR mediates the occurrence and progression of DILI. This article aims to briefly review the role and mechanisms of PXR in DILI.