Hyperuricemia(HUA) is a pathological condition characterized by elevated levels of uric acid in the blood,which can adversely affect female reproductive health by altering the functions of the uterus and ovaries.Epigenetic modifications, primarily influenced by environmental factors,regulate gene expression without changing the gene sequence,thereby affecting individual metabolism,and being transmitted to the offspring through epigenetic imprinting. The occurrence of HUA results from the interaction between genetic and environmental factors. Understanding the underlying epigenetic mechanisms is of great significance for effective prevention and treatment of HUA and its complications. This article discusses in detail the effects of maternal HUA on pregnancy complications,gestational metabolic syndrome,and offspring health. It summarizes the epigenetic regulatory mechanisms of HUA, aiming to elucidate the pathogenesis of HUA at the molecular level and provide new research insights for reducing maternal pregnancy risks.