Ferroptosis is a non-apoptotic form of cell death that integrates metabolic disorders, oxidative stress, and inflammation, characterized by the accumulation of iron-dependent lipid peroxidation. A growing body of literature suggests that ferroptosis is involved in the pathogenesis of chronic respiratory diseases. In addition, there is a notable association between ferroptosisrelated genes and molecules and chronic respiratory diseases, indicating their potential as disease biomarkers. This article summarizes the research progress on the role of ferroptosis in chronic respiratory diseases, discusses the advances in existing therapies targeting ferroptosis in chronic respiratory diseases, and highlights the main obstacles in translating experimental research into clinical applications, with the aim of providing new insights for the treatment of chronic respiratory diseases.