Myokines exert a significant beneficial effect on cardiovascular and metabolic diseases. As a recently identified myokine, myonectin is closely associated with various cardiovascular and metabolic diseases, such as coronary heart disease, diabetes, and obesity. This article reviews the biological characteristics of myonectin, its role in the occurrence and development of cardiovascular and metabolic diseases, and its potential mechanisms of action, aiming to provide new targets and strategies for the prevention and treatment of cardiovascular and metabolic diseases.