The main function of sebaceous glands (SG) is producing sebum, which is an integral component of the skin barrier, regulates the growth of cutaneous microbiota via its acid and antimicrobial lipid content, and modulates skin inflammation and immunity. Dysfunctions of SG play critical roles in the pathogenesis of common dermatoses such as acne, seborrhea, and atopic dermatitis. The endocannabinoid system (ECS) is a complex homeostatic signaling network that comprises endocannabinoids, cannabinoid receptors, and enzymes responsible for endocannabinoid transport, synthesis, and degradation. Recent evidence has indicated the expression and functional involvement of ECS components in human SGs, suggesting the therapeutic potential of ECS modulation in the management of SG-associated diseases. This review provides an overview of research progress on the regulatory effects of ECS on SG functions.