Monograph

Research Progress on Suplatast Tosilate in Th2 Cell-Mediated Allergic Diseases

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  • (1Department of Immunology, School of Basic Medicine, Peking University, Beijing 100191, China; 2Key Laboratory of Medical Immunology, National Health Commission, Beijing 100191, China; 3Laboratory of Pathogens and Immunology, Biomedical Experimental Teaching Center, Peking University, Beijing 100191, China; 4Peking University School of Pharmaceutical Sciences, Beijing 100191, China; 5Peking University School and Hospital of Stomatology, Beijing 100081, China; 6Nanyang Medical College, Nanyang 473000, China)
# Co-first   △WANG Yue-Dan, Email:wangyuedan@bjmu.edu.cn

Received date: 2023-11-21

  Revised date: 2023-12-20

  Accepted date: 2023-12-22

  Online published: 2024-08-25

Abstract

Suplatast Tosilate is a specific Th2 cell inhibitor that has been widely used in the treatment of various allergic and inflammatory diseases such as asthma and atopic dermatitis, with good efficacy and high safety. Research has shown that Suplatast Tosilate can inhibit the production and function of Th2 cells and Th2-type cytokines such as IL-4 by regulating GATA3 and chloride channels, thereby exerting a therapeutic effect on allergic diseases. Additionally, Suplatast Tosilate also has regulatory effects on dendritic cells, monocytes, eosinophils, and neurons. Therefore, Suplatast Tosilate has become a focus of attention in the research field of treating Th2 cell-mediated allergic inflammatory diseases.

Cite this article

QI Zi-Hui1, 2, 3, 4, # , ZHU Xi-Run1, 2, 3, 4, # , YIN Yin1, 2, 3, 5, # , WANG Ge-Xin6, LIU Yuan1, 2, 3, CHU Ming1, 2, 3, WANG Yue-Dan1, 2, 3, △ . Research Progress on Suplatast Tosilate in Th2 Cell-Mediated Allergic Diseases[J]. Progress in Physiological Sciences, 2024 , 55(4) : 369 -375 . DOI: 10.20059/j.cnki.pps.2024.03.1143

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