The relative balance of intestinal flora is a prerequisite for body health, and the imbalance of intestinal flora is associated with the occurrence and development of Parkinson's disease. Aerobic exercise plays an important role in the prevention and treatment of Parkinson's disease, which has been observed to regulate the composition and diversity of intestinal flora in both animal models and patients with Parkinson’s disease, suggesting a close relationship between aerobic exercise, intestinal flora and Parkinson's disease. However, the mechanism by which aerobic exercise improves Parkinson's disease by regulating the intestinal flora has not been fully clarified. Therefore, this article mainly reviews Parkinson 's disease and the microbiota-gut-brain axis, the effects of aerobic exercise on the motor and non-motor symptoms of Parkinson 's disease, and the potential mechanisms by which aerobic exercise improves Parkinson 's disease through the regulation of intestinal flora, aiming to provide reference for the prevention and treatment of Parkinson's disease by regulating intestinal flora through aerobic exercise.