Pathological myocardial hypertrophy is a response to injury when the heart is subjected to continuous pressure overload and other stimuli, which can induce cardiovascular diseases with high mortality such as sudden cardiac death and heart failure. Currently, there is no effective treatment for pathological myocardial hypertrophy. Non-coding RNAs (ncRNAs) refer to RNA molecules that are not translated into proteins in the transcriptome but play important regulatory roles in the body. Recent studies have found changes in the expression of multiple ncRNAs in the model of pathological myocardial hypertrophy, which participate in myocardial hypertrophy by regulating various molecules and signaling pathways. In this article, we reviewed the current findings of long non-coding RNAs (lncRNAs) related to pathological myocardial hypertrophy and their associated mechanisms in the occurrence and development of pathological myocardial hypertrophy, in order to provide novel insights for the prevention and treatment of myocardial hypertrophy.