Cardiometabolic disease (CMD) refers to the single or simultaneous occurrence of pathological changes in the metabolic and cardiovascular systems that can mutually influence each other, which is a collective term for metabolic and cardiovascular diseases,including obesity,insulin resistance,metabolic syndrome,diabetes,and coronary heart disease, etc. Adipokines play a critical role in the occurrence and development of CMD. Complement C1q TNF-related protein 7 (CTRP7) is a recently discovered adipokine closely associated with CMD, such as obesity, diabetes and coronary heart disease. Focusing on the biological characteristics of CTRP7, this article reviews its role in the occurrence and development of CMD, including obesity, type 2 diabetes mellitus and coronary heart disease, as well as the possible mechanisms such as regulating glucose and lipid metabolism, decreasing insulin sensitivity, promoting inflammatory responses and increasing oxidative stress, so as to provide evidence and references for CTRP7 as a therapeutic target of CMD.