Parkinson's disease (PD) is a common neurodegenerative disease with not only typical cardinal motor features such as resting tremor, bradykinesia, rigidity and gait disorders, but also motor learning deficits characterized by difficulties in learning new motor skills and follow-up execution, which seriously affect patients’ quality of life. Thus, it is of crucial importance to clarify the cause and pathological mechanism of motor learning deficits in PD. Based on the different forms and stages of motor learning, this review summarizes the characteristics of motor learning deficits in PD, the related neural circuits and neurotransmitters, as well as recent therapies, aiming to investigate the mechanism of motor learning deficits in PD and provide new strategies for its prevention and rehabilitation.