Autophagy disorder is involved in various cardiovascular diseases, including atherosclerosis, abdominal aortic aneurysm, pulmonary hypertension, myocardial ischemia-reperfusion injury, and heart failure. Physiological autophagy plays a crucial role in maintaining cardiovascular homeostasis. Herein, we review the existing research on the role of autophagy in preserving cardiovascular homeostasis and regulating the pathological processes of cardiovascular diseases. Additionally, focusing on cyclic stretch, a type of mechanical stimulation, we review the potential roles and mechanisms of mechanical stimulation in cytoskeleton remodeling and autophagy regulation. Targeting autophagy offers promising prospects for potential interventions in the diagnosis and treatment of cardiovascular diseases.