糖脂代谢性疾病以糖代谢、脂代谢紊乱为特征,主要涉及神经内分泌失调、胰岛素抵抗、氧化应激、炎症反应和肠道菌群失调等多方面病理机制,糖脂代谢紊乱可导致2型糖尿病、血脂异常、肥胖症、心血管疾病和代谢相关脂肪性肝病等多种疾病的发生发展。近年来,乳酸化修饰(lactylation modification)作为一种新型酰基化修饰而受到广泛关注,在调节蛋白质的功能中发挥着重要作用, 并参与细胞内基因表达及多种信号通路调节。本文将对乳酸化修饰在糖脂代谢性疾病中的调控作用及研究进展进行综述,并探讨其作为潜在治疗靶点的可能性,以期为糖脂代谢性疾病的防治提供新思路。

Glycolipid metabolic diseases are characterized by disorders of glucose and lipid metabolism, which involve multiple pathological mechanisms, including neuroendocrine dysregulation, insulin resistance, oxidative stress, inflammatory responses, and gut microbiota dysbiosis. Glycolipid metabolic disorders can lead to the occurrence and development of various diseases, such as type 2 diabetes, dyslipidemia, obesity, cardiovascular diseases, and metabolic-associated fatty liver disease. In recent years, as a newly identified acylation modification, lactylation modification has attracted considerable attention. It plays a crucial role in regulating protein function, and participates in the regulation of intracellular gene expression and a variety of signaling pathways. This article reviews the regulatory roles and research progress of lactylation modification in glycolipid metabolic diseases, explores its potential as a therapeutic target, with the aim of providing new insights into the prevention and treatment of glycolipid metabolic diseases.