乳腺癌作为女性发病率最高的恶性肿瘤,其转移性和耐药性是导致患者高死亡率的重要原因。近年来,代谢重编程已被证实在乳腺癌的发生发展中发挥关键作用。既往研究主要聚焦于糖代谢异常,对脂肪酸(fatty acids, FA)代谢的研究相对较少。最新研究表明,乳腺癌细胞通过异常激活FA 摄取、合成、储存及氧化分解等代谢途径,为其快速增殖、转移和耐药提供能量和生物合成前体。本文系统综述了乳腺癌FA 代谢重编程的最新研究进展,并深入探讨潜在的治疗靶点及靶向干预策略。

Breast cancer, the most prevalent malignant tumor in women, exhibits high mortality rates primarily due to its metastatic potential and drug resistance. In recent years, metabolic reprogramming has been proven to play a critical role in the occurrence and development of breast cancer. Previous research has mainly focused on aberrant glucose metabolism, with limited investigation of fatty acid metabolism. Recent studies have shown that breast cancer cells provide energy and biosynthetic precursors for rapid proliferation, metastasis, and drug resistance by abnormally activating fatty acid metabolic pathways including uptake, synthesis, storage, and oxidative decomposition. This article systematically reviews the latest research progress on fatty acid metabolic reprogramming in breast cancer, and provides an in-depth exploration of potential therapeutic targets and targeted intervention strategies.