肿瘤的发生发展与RNA 结合蛋白(RNA-binding proteins, RBPs)介导的转录后调控异常密切相关。RBPs通过调控mRNA 剪接、稳定性及翻译等过程,在肿瘤进展中发挥关键作用。本综述系统梳理了肿瘤发生发展过程中导致RBPs表达或功能异常的分子机制,RBPs通过调控肿瘤相关信号转导通路促进肿瘤进展的分子基础及其在肿瘤恶性转化和治疗抵抗中的作用,以期为开发靶向RBPs的抗肿瘤治疗提供重要的理论依据。

Tumor development is closely related to the aberrant post-transcriptional regulation mediated by RNA-binding proteins (RBPs), which play a key role in tumor progression by regulating mRNA splicing, stability, and translation. This review systematically investigates the molecular mechanisms underlying the abnormal expression or dysfunction of RBPs during tumor development, the molecular basis of RBPs in promoting tumor progression through regulating tumor-associated signalling pathways, and the roles of RBPs in malignant transformation and therapeutic resistance, aiming to provide an important theoretical basis for developing anti-tumor therapies targeting RBPs.