咖啡作为全球广泛消费的饮品,其与肝脏健康的关联备受关注。本文基于国内外最新研究, 系统综述了咖啡摄入对慢性肝脏疾病的预防及保护作用,重点探讨了咖啡在代谢相关脂肪性肝病(metabolic dysfunction-associated fatty liver disease, MAFLD)、肝癌等慢性肝病中发挥的保护作用及其潜在分子机制。研究显示,适量饮用咖啡可通过抗炎、抗氧化及调节代谢等途径改善肝脏功能和健康,且存在性别和人群差异。本文结合临床实证数据与相关机制研究,提供了关于咖啡在慢性肝病中作用的理论依据和参考,并给出咖啡饮用的科学建议。

Coffee, as a globally prevalent beverage, has garnered considerable research attention regarding its association with liver health. Drawing upon recent domestic and international research, this article systematically reviews the preventive and protective effects of coffee consumption on chronic liver diseases. Specifically, it focuses on the protective roles of coffee in diseases such as metabolic dysfunction-associated fatty liver disease (MAFLD), liver cancer, and other chronic liver diseases, as well as the underlying molecular mechanisms. Evidence indicates that moderate coffee intake enhances liver function and health primarily via anti-inflammatory, antioxidant, and metabolic regulatory pathways. Notably, these effects exhibit variations across genders and populations. By integrating clinical evidence with mechanistic research, this review provides a theoretical basis and reference for understanding the role of coffee in chronic liver diseases, and offers scientific recommendations for coffee consumption.