生理科学与临床

“咖啡与健康”系列——肠道菌群:咖啡与代谢健康的新桥梁

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  • (北京大学医学部基础医学院生理学与病理生理学系, 北京 100191)
△ kangjihong@bjmu.edu.cn

收稿日期: 2025-10-10

  修回日期: 2025-10-14

  录用日期: 2025-10-17

  网络出版日期: 2025-12-25

基金资助

北大医学瑞幸健康创新基金RX-CX202501资助课题

The Gut Microbiota: A New Link Between Coffee and Metabolic Health

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  • (Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China)
△ kangjihong@bjmu.edu.cn

Received date: 2025-10-10

  Revised date: 2025-10-14

  Accepted date: 2025-10-17

  Online published: 2025-12-25

摘要

咖啡作为全球广泛消费的饮品,其代谢健康效应日益受到关注。本文探讨了咖啡通过肠道菌群影响代谢的潜在机制,综述了咖啡中的多酚和咖啡因在肠道微生物作用下转化为短链脂肪酸(short-chain fatty acids,SCFAs)和其他代谢产物,进而参与调控糖代谢、脂质代谢、炎症反应和胆汁酸代谢的机制。

本文引用格式

李砚霓#, 康继宏△ . “咖啡与健康”系列——肠道菌群:咖啡与代谢健康的新桥梁[J]. 生理科学进展, 2025 , 56(6) : 593 -599 . DOI: 10.20059/j.cnki.pps.2025.11.1228

Abstract

Coffee, a globally consumed beverage, has gained increasing attention for its effects on metabolic health. In this review, we explore the potential mechanisms by which coffee influences metabolism through the gut microbiota. Specifically, we review the mechanisms by which coffee polyphenols and caffeine are metabolized by gut microbes into short-chain fatty acids (SCFAs) and other metabolites, which subsequently regulate glucose metabolism, lipid metabolism, inflammatory responses, and bile acid metabolism.
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