乳酸化修饰(lactylation modification)是近年来新发现的一种蛋白质翻译后修饰, 其在基因表达和细胞代谢等病理生理过程以及疾病治疗中发挥着重要作用,但在口腔医学领域的研究还处于起步阶段。本文综述了乳酸化修饰的调控机制和影响因素,并对乳酸化修饰在牙周炎、口腔鳞状细胞癌、正畸治疗和牙发育等口腔医学领域的研究状况进行阐述,为该领域疾病的防治、靶向治疗和药物研发等提供新的方向和策略。

Lactylation modification, a recently identified post-translational modification of proteins, plays a crucial role in various pathophysiological processes such as gene expression and cellular metabolism, and contributes to disease treatment. However, research on lactylation modification in the field of stomatology remains in its initial stages. This article reviews the regulatory mechanisms and influencing factors of lactylation modification, and details recent advances in its roles within stomatology, covering periodontitis, oral squamous cell carcinoma, orthodontic treatment, and tooth development, with the aim of providing new directions and potential breakthroughs for disease prevention, targeted therapy, and drug development in this field.