胃癌是我国最常见的上消化道恶性肿瘤之一, 绝大多数患者在确诊时已处于进展期, 临床预后较差。叉头框O(forkhead box O,FOXO)是一类广泛存在于真核生物中的转录因子,在发育、代谢以及恶性肿瘤的发生发展等多种生理和病理过程中发挥关键作用。临床研究发现,FOXO 在胃癌中异常表达,并且与胃癌的增殖、迁移、治疗及耐药等密切相关。本文概述了FOXO 的调控机制、FOXO 在胃癌发生发展中的作用及其作为胃癌治疗靶点的可能性。

Gastric cancer is one of the most common upper gastrointestinal malignancies in China, with a significant proportion of patients diagnosed at advanced stages, leading to a poor clinical prognosis. Forkhead box O (FOXO) is a class of transcription factors widely present in eukaryotes, playing key roles in various physiological and pathological processes, including development, metabolism, and the occurrence and progression of malignant tumors. Clinical studies have demonstrated that FOXO is abnormally expressed in gastric cancer and is closely associated with its proliferation, migration, treatment response, and drug resistance. This article summarizes the regulatory mechanisms of FOXO, its role in the occurrence and progression of gastric cancer, and its potential as a therapeutic target for the disease.