长链非编码RNA(long noncoding RNAs,lncRNAs)是一类长度超过 200 个核苷酸的不具有蛋白质编码功能的 RNA 分子,在转录后和表观遗传水平发挥调节作用。研究表明,lncRNAs 在糖脂代谢、肝脏组织纤维化、炎症反应、肿瘤的发生发展及肝细胞自噬等细胞功能中发挥着关键作用。非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)的发病机制越来越受到关注, 本文详细阐述了 lncRNA 与 NAFLD 发病机制的密切关系,预测lncRNA 作用的新靶点,为 NAFLD 的研究和防治提供研究基础和新思路。

Long noncoding RNAs (lncRNAs) are a class of RNAs exceeding 200 nucleotides in length that lack protein-coding capabilities, and play crucial roles in the regulation of gene expression and epigenetic modifications at the post-transcriptional level. Research has demonstrated that lncRNAs are integral to various cell functions, including glucose metabolism, lipid metabolism, liver tissue fibrosis, inflammatory responses, tumorigenesis, and hepatocyte autophagy. The pathogenesis of non-alcoholic fatty liver disease (NAFLD) is gaining increasing attention. This article offers a comprehensive analysis of the intricate relationship between lncRNAs and the pathogenesis of NAFLD, identifies novel targets for lncRNA action, and lays a foundational framework along with innovative perspectives for future research and prevention of NAFLD.