高温需求因子A3(high-temperature requirement factor A3, HtrA3)是一种丝氨酸蛋白酶, 目前已被研究证实是癌症、妊娠并发症等疾病的重要靶分子,该分子的调控作用得益于其广泛的生物学功能,但目前尚缺乏对这一方面的有效整合和系统阐述。本文针对HtrA3的生物学功能如参与蛋白质质量控制、免疫调控;调节线粒体稳态和细胞凋亡、细胞外基质降解和上皮间质转化; 调节细胞的增殖和迁移等进行了论述。此外,研究证实HtrA3在心脏中的表达量最高,目前已有该分子在心肌纤维化、心力衰竭、缺血再灌注损伤中的相关报道。基于其功能广泛,HtrA3或可作为心血管疾病的重要调节因子,在心血管疾病的发展中具有重要研究价值。

High-temperature requirement factor A3 (HtrA3) is a serine protease, which has been identified as an important target molecule in diseases such as cancer and pregnancy complications. The regulatory role of this molecule is attributed to its extensive biological functions. However, there is still a lack of effective integration regarding this aspect. Therefore, in this article, we discuss the biological functions of HtrA3,including its involvement in protein quality control, immune regulation,maintenance of mitochondrial homeostasis,apoptosis,extracellular matrix degradation, and epithelial-mesenchymal transformation, as well as its role in regulating cell proliferation and migration. In addition, studies have confirmed that HtrA3 is predominantly expressed in the heart, with significant research progress made regarding this molecule in the contexts of myocardial fibrosis, heart failure, and ischemia-reperfusion injury. Given its extensive functions, HtrA3 may serve as a significant regulator of cardiovascular diseases, highlighting its important research value in the development of cardiovascular diseases.