牙周炎(periodontitis)是一种常见的口腔疾病,是成年人牙齿缺失的主要原因。牙龈上皮组织是抵御外界侵袭的第一道防线,牙周炎的发生发展与多种致病菌侵袭破坏牙龈上皮组织密切相关。已有研究表明,牙周炎致病菌通过一系列毒力因子,破坏牙龈上皮组织,侵入深层组织,并引发炎症反应。其中,牙龈卟啉单胞菌(Porphyromonas gingivalis)是牙周炎的主要致病菌。本文将从牙龈卟啉单胞菌对牙龈上皮的调控进行综述,以期为牙周炎的治疗提供参考。

Periodontitis is a common oral disease and the leading cause of tooth loss in adults. The gingival epithelium is the first line of defense against external invasions. The occurrence and development of periodontitis are closely related to the invasion and destruction of the gingival epithelium by various pathogenic bacteria. Research has demonstrated that periodontitis-associated pathogens destroy the gingival epithelium,invade deep tissues,and trigger inflammatory responses through a series of virulence factors. Among them, Porphyromonas gingivalis is the main cause of periodontitis. This article reviews the regulatory effects of Porphyromonas gingivalis on the gingival epithelium, with the aim of providing a reference for the treatment of periodontitis.