肝脏在转化、清除异源物的过程中发挥重要作用。持续暴露于高浓度的异源物会导致肝功能受损,称为药物诱导性肝损伤(drug-induced liver injury, DILI)。核受体超家族成员孕烷X 受体(pregnane X receptor, PXR)作为肝脏药物清除系统的重要调控因子,通过调节药物代谢酶(drug metabolizing enzymes, DMEs)和转运体的表达,在肝脏药物转化、代谢与清除中发挥重要作用。研究证明PXR参与DILI的发生发展。本文旨在阐述PXR在DILI中的作用及其机制研究进展。

The liver plays a crucial role in the transformation and clearance of xenobiotics.However, continuous exposure to high concentrations of these foreign substances can lead to liver damage,known as drug-induced liver injury (DILI).The pregnane X receptor (PXR), a member of the nuclear receptor superfamily,is a key regulator of hepatic drug clearance.PXR regulates the expression of drug-metabolizing enzymes and transporters,and plays an essential role in drug transformation, metabolism, and clearance in the liver. Studies have shown that PXR mediates the occurrence and progression of DILI. This article aims to briefly review the role and mechanisms of PXR in DILI.