高尿酸血症(hyperuricemia,HUA)是血液中尿酸水平过高的病理状态,能通过改变子宫和卵巢的功能影响雌性生殖健康。表观遗传修饰主要受环境作用,能在不改变基因序列的前提下调控基因表达进而影响个体代谢,并通过表观遗传标记传递给后代。HUA 的发生是遗传因素与环境因素共同作用的结果,了解其背后的表观遗传机制,对于有效防治HUA 及其并发症有重要意义。本文详细讨论了母体患有HUA 时,对妊娠并发症、妊娠期代谢综合征以及后代健康的影响, 并总结了HUA 的表观遗传调控机制,旨在阐明HUA 分子水平的发病机理,为降低母体妊娠风险提供新的研究思路。

Hyperuricemia(HUA) is a pathological condition characterized by elevated levels of uric acid in the blood,which can adversely affect female reproductive health by altering the functions of the uterus and ovaries.Epigenetic modifications, primarily influenced by environmental factors,regulate gene expression without changing the gene sequence,thereby affecting individual metabolism,and being transmitted to the offspring through epigenetic imprinting. The occurrence of HUA results from the interaction between genetic and environmental factors. Understanding the underlying epigenetic mechanisms is of great significance for effective prevention and treatment of HUA and its complications. This article discusses in detail the effects of maternal HUA on pregnancy complications,gestational metabolic syndrome,and offspring health. It summarizes the epigenetic regulatory mechanisms of HUA, aiming to elucidate the pathogenesis of HUA at the molecular level and provide new research insights for reducing maternal pregnancy risks.