心血管疾病严重影响人类健康,为亟待解决的公共卫生问题。线粒体代谢产生的活性氧是其发生发展的危险因素,当线粒体功能障碍时将产生过量活性氧,内源抗氧化系统无法清除过量活性氧时,会发生氧化应激损伤,损害心血管健康。通过营养干预手段改善线粒体功能,减少活性氧,是防治心血管疾病的重要途径。甲磺酸米托醇(mitoquinol mesylate,MitoQ)作为线粒体靶向抗氧化剂,可靶向积聚在线粒体内膜,淬灭线粒体活性氧。本文综述了MitoQ 的分子特性和作用机制及其改善心血管疾病的功效,并对比MitoQ 与辅酶Q10 的异同,为MitoQ 将来在心血管疾病防治方面的应用提供科学依据。

Cardiovascular diseases significantly affect human health and represent an urgent public health issue that needs to be addressed.Reactive oxygen species (ROS) generated by mitochondrial metabolism are risk factors for the occurrence and progression of cardiovascular diseases. When mitochondrial function is impaired,excess ROS are generated.If the endogenous antioxidant system fails to eliminate the excess ROS,oxidative stress damage occurs,thereby compromising cardiovascular health.Therefore,improving mitochondrial function and reducing ROS through nutritional interventions has become a crucial approach to prevent and treat cardiovascular diseases.Mitoquinol mesylate (MitoQ),a mitochondria-targeted antioxidant,accumulates in the inner mitochondrial membrane,quenching mitochondrial ROS.This article reviews the molecular properties and mechanisms of action of MitoQ,as well as its benefits in improving cardiovascular diseases.Additionally,it compares the similarities and differences between MitoQ and coenzyme Q10 (CoQ10),providing a scientific basis for the future application of MitoQ in the treatment of cardiovascular diseases.