肠道菌群能够通过代谢产物对宿主多种生理过程产生调控作用,对人体健康至关重要。丙酸咪唑(imidazole propionate)是肠道菌群代谢组氨酸生成的一种代谢产物。近年来,丙酸咪唑由于与2型糖尿病、心血管疾病等慢性疾病的密切关联而受到广泛关注。本文综述了丙酸咪唑的代谢途径、与代谢性疾病和心血管疾病的相关性及其作用机制,以及现有的检测和干预方法,以期为以丙酸咪唑为靶点的慢性疾病防控提供参考。

Metabolites produced by the gut microbiota play various physiological regulatory roles through interactions with the host and are closely related to human health. Imidazole propionate, a metabolite derived from histidine by the gut microbiota, has garnered significant attention in recent years due to its close association with chronic diseases such as type 2 diabetes and cardiovascular diseases. This article reviews the metabolic pathways of imidazole propionate, its correlation with metabolic and cardiovascular diseases, its mechanisms of action, and current methods for its detection and associated interventions. The aim is to provide a reference for the prevention and control of chronic diseases targeting imidazole propionate.